Ans:
依據國動(NCB)官網,此一病變應屬眼瞼緣炎 (blepharitis),有時會導致結膜炎。依據文獻資料,眼瞼緣炎或眼瞼緣結膜炎 (blepharoconjunctivitis) 好發於BALB/cByJ、BALB/cJ、CBA/J、129/J及A/HeJ等品系,為一自發性病變,發生率有隨年紀增加而升高的趨勢,可能與遺傳有關 (因為DBA/2J較不易發生),也有可能是感染造成 (病灶可分離到 Pasteurella pneumotropica ,但由於沒有病變的眼瞼亦可分離到此菌,因此可能為機會感染造成),有人則認為原因不明。由於可能為機會感染,因此提升或改善飼育環境,或許可降低發生率。
參考文獻:
Smith, R. S. and J. P. Sundberg (1996). Ulcerative blepharitis in aging inbred mice.
Pathobiology of the Aging Mouse. M. U., D. D.L., C. C.C.et al. Washington, D.C., ILSI press. 2: 130-138.
JAX NOTES, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
Ans:
According to the National Center for Biomodels (NCB), this condition is likely the blepharitis, which can sometimes lead to conjunctivitis. According to literature, blepharitis or blepharoconjunctivitis is common in strains such as BALB/cByJ, BALB/cJ, CBA/J, 129/J, and A/HeJ. It is a spontaneous condition, with an increasing incidence with age. It may be genetic (as DBA/2J is less susceptible) or due to infection (Pasteurella pneumotropica has been isolated from lesions, but since this bacteria can also be isolated from eyelids without lesions, it may be an opportunistic infection). Some believe the cause is unknown. Since it may be an opportunistic infection, improving the breeding environment may reduce its incidence.
References:
Smith, R. S. and J. P. Sundberg (1996). Ulcerative blepharitis in aging inbred mice.
Pathobiology of the Aging Mouse. M. U., D. D.L., C. C.C. et al. Washington, D.C., ILSI press. 2: 130-138.
JAX NOTES, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
